Clément Brun began his acting career at a very young age, stepping into the world of café-théâtre where he trained in improvisation, among other disciplines. He continued his formal education by enrolling in his city's Conservatory of Dramatic Arts (where he was awarded the Gold Medal)and subsequently at the Théâtre National de Nice.

At the age of 20, he turned his focus to stand-up comedy. He wrote, directed, and performed his first one-man show, which led to opportunities to open for major French artists such as Michaël Grégorio, Roland Magdane, and Titoff. Simultaneously, he continued to act in both contemporary and classical theater productions.

He landed his first feature film role playing Ludo in Je vous aime très beaucoup, directed by Philippe Locquet.

In 2012, he was cast as Rémy, the young assistant to Juliette (Anne Girouard), in No Limit on TF1, the first television series produced by Luc Besson. A year later, his first one-man show was adapted into a short film titled Retenez bien ma gueule !. He played the lead role in the film, acting opposite director Georges Lautner and actors Daniel Russo and Michel Crémadès.

Clément Brun has since appeared in numerous television productions, notably including Le Piège Afghan, Section de Recherches, Plus Belle la Vie, Un Père Coupable, Scènes de Ménages, Meurtres au Mont Ventoux, and Meurtres à Grasse.

On stage, Clément Brun has demonstrated his versatility in both classical and contemporary repertoires. His theater credits include key roles in Molière's Les Fourberies de Scapin and Shakespeare's A Midsummer Night's Dream, as well as a tour with Les Monologues de Feydeau.

As a stand-up comedian, he followed his initial success with several other solo shows, including the diptych Retenez bien ma tête, demain je serai chômeur ! and its sequel Retenez bien ma tête, 2main je serai chômeur !, followed by Je t'aime d'Humour. He is currently touring with his latest high-energy one-man show, Explose.