Ntare Guma Mbaho Mwine next stars in two new highly anticipated series. He first stars opposite Taron Egerton in the new AppleTV series "Smoke" from celebrated writer Dennis Lehane which will premiere on June 27th. Mwine also stars opposite Michael C. Hall in the Paramount+/Showtime series "Dexter: Resurrection" from famed writers Clyde Phillips and Scott Reynolds, which is also due out in summer 2025. Mwine previously starred opposite Rachel Weisz in the 2024 Peabody Award-winning Alice Birch series "Dead Ringers," on Amazon, based on David Cronenberg's 1988 thriller. Mwine also played Detective Raymond Griggs in the David E. Kelley/Ted Humphrey Netflix hit series "The Lincoln Lawyer," based on Michael Connelly's best-selling novels. Mwine's extensive television credits include his critically acclaimed portrayal of Ronnie, the complex anti-hero in Lena Waithe's Showtime series "The Chi." Variety, The Boston Globe, Roger Ebert and The New York Times all singled out Mwine in their reviews with NY Times stating that "Mr. Mwine is especially remarkable as the precariously balanced Ronnie." Mwine played the lead role in the series finale of HBO's "Room 104" and previously portrayed recurring roles in Steven Soderbergh's Cinemax series "The Knick," David Simon and Eric Overmyer's HBO series "Treme," Eric Overmyer's Amazon series "Bosch," and Tim Kring's NBC series "Heroes."

The Los Angeles Times listed Mwine as one of the biggest breakout stars of Sundance 2020, and he was awarded (the coveted) Best Actor at the 2020 Durban International Film Festival for his lead performance in Ekwa Msangi's award-winning film "Farewell Amor." Mwine was also singled out in Variety and The Hollywood Reporter's reviews of the film, with the latter stating that "Mwine stuns with his elegant pauses and piercing stares that seem to jump through the screen." Furthermore, the film was named one of the Top Ten Independent Films by the National Board of Review.

Previous film acting credits include Mira Nair's "Queen of Katwe," opposite Lupita Nyong'o and "Blood Diamond," opposite Leonardo DiCaprio from director Ed Zwick. Mwine's work as a feature length and short film director has resulted in multiple awards. His short film "Kuhani," won the main prize for Best Achievement in Directing at the Oscar-qualifying International Kurzfilmtage Winterthur in Switzerland and was nominated for the Grand Jury Prize for Best Short Film at Slamdance. Mwine's documentary feature "Memories of Love Returned," was named one of the "Ten Best African Documentaries of 2024" by OkayAfrica. It has also earned multiple accolades, including the Audience Award for Best Feature Documentary at the Pan African Film Festival, Best Documentary at the Silicon Valley African Film Festival, Best International Documentary, and a Jury Special Mention at the African International Film Festival. The film spotlights the life and work of the late great Ugandan photographer Kibaate Aloysius Ssalongo, which Steven Soderbergh Executive Produced.