Olisa Odele is an English actor. He played Yemi on all three series of Channel 4 coming-of-age comedy drama series Big Boys (2022-2025). As a child actor, he previously appeared in forty episodes of My Parents are Aliens (2004-2005).

His early television appearances included forty episodes of My Parents are Aliens. He played Ola in Michaela Coel's series Chewing Gum on E4. He also appeared in It’s a Sin. In 2019, he appeared in BBC One comedy series Scarborough.

He had a main role as Yemi in all three series of Jack Rooke created Channel 4 coming-of-age comedy drama series Big Boys, with his performance described as "regally characteristic".

He played Peter in 2024 British comedy series Dead Hot which aired on Amazon Prime Video. He appeared on stage as Isom in the British National Theatre tour of comedy stage play The Hot Wing King in 2024.

In February 2025, he could be seen in both series of Daisy May Cooper comedy drama series Am I Being Unreasonable? on BBC One.