The O. Henry Playhouse was an early American anthology television series which featured television adaptations of short stories written by 19th-century author O. Henry and primarily set in New York City. The series was both hosted and narrated by Thomas Mitchell, who portrayed the title character, and featured several television and film stars during its run such as DeForest Kelley, Lisa Montell, Otto Kruger, Max Showalter and Ernest Borgnine. The series was syndicated and initially ran from January 23 to May 25, 1957, and its final episode aired on November 19 of that year.

Thomas Mitchell

Preston Foster
John McCaskey

Kathleen Freeman
Maggie McCaskey
Paul Engle
Terry Moran

Thomas Browne Henry
Mister Toomey

Elaine Riley
Mrs. Moran
Jess Kirkpatrick
Tim
Perk Lazelle
Vendor

Jim Davis
Robert Arnold
Silk75%
Tales of the Unexpected68%
Dangerous Liaisons62%
The New Avengers71%
Downton Abbey81%
Jack Irish67%
Chesapeake Shores78%
Road to Avonlea82%
Hotel68%
Lady Chatterley63%
R. L. Stine's The Haunting Hour82%
Carl Weber's The Family Business85%
When Calls the Heart82%
Mosaic65%
Scarecrow and Mrs. King65%
Resurrection72%
Voyage to the Bottom of the Sea77%
Pride and Prejudice82%
North & South80%
Crime Story79%