He is a Turkish-Italian director, screenwriter and writer. In 1976, he first went to Perugia Foreigners University in Italy, learned Italian for a year, and then transferred to Rome La Sapienza University to study cinema. After completing his education there, he went to Accademia Navona and Accademia d'Arte Dramatica schools to study art history, costume and theater direction and took lessons from Silvio D'Amico. During this period, he worked with Julien Beck in various positions on the European tour of The Living Teather. In 1982, he was assistant director to Massimo Troisi in the film Scusate il Ritardo, and later to Maurizio Ponzi in the film Son Contento. Ferzan Özpetek worked as an assistant director for nearly 15 years with different directors such as Ricky Tognazzi, Lamberto Bava, Francesco Nuti, Sergio Citti, Giovanni Veronesi and Marco Risi.

American singer Madonna stated that Ferzan Özpetek was "a genius" in an interview with a television program. Özpetek received congratulations from names such as John Travolta and Andy Garcia after the screening of his 2009 film, Serseri Mayinlar, at the opening of the Los Angeles Film Festival.

Ferzan Özpetek served as the jury president of the committee consisting of actors Hülya Kocyigit, Zuhal Olcay, Aytac Arman, Kenan Isik and director Nuri Bilge Ceylan at the 42nd Antalya Golden Orange Film Festival held in 2005.

In 2007, he was a jury member at the 75th Venice Film Festival.